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In clinically isolated syndromes, the new McDonald criteria for multiple sclerosis diagnosis require new gadolinium-enhancing lesions for dissemination in time at a 3-month follow-up magnetic resonance imaging scan. In a cohort of 56 patients, these criteria were specific (95%) but less sensitive (58%) for clinically definite multiple sclerosis at 3 years. If new T2 lesions were allowed as an alternative for dissemination in time, sensitivity increased (74%) with maintained specificity (92%), enabling an accurate diagnosis of multiple sclerosis in more patients. |
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gadolinium
MRI
MRI,abnormal
MRI,contrast enhanced
MRI,demyelinating disease
multiple sclerosis
multiple sclerosis,diagnosis of
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multiple sclerosis,monosymptomatic
neurologic disease,diagnoses of
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